The interaction between filarial parasites and human monocyte/macrophage populations.
Identifieur interne : 003067 ( Main/Exploration ); précédent : 003066; suivant : 003068The interaction between filarial parasites and human monocyte/macrophage populations.
Auteurs : Roshanak Tolouei Semnani [États-Unis]Source :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 2013.
Descripteurs français
- KwdFr :
- Activation des macrophages, Animaux, Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Cytokines (biosynthèse), Cytokines (immunologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Interactions hôte-parasite, Lymphocytes T (anatomopathologie), Lymphocytes T (immunologie), Lymphocytes T (parasitologie), Macrophages (anatomopathologie), Macrophages (immunologie), Macrophages (parasitologie), Monocytes (anatomopathologie), Monocytes (immunologie), Monocytes (parasitologie), Souris, Spécificité d'hôte.
- MESH :
- anatomopathologie : Lymphocytes T, Macrophages, Monocytes.
- biosynthèse : Cytokines.
- immunologie : Antigènes d'helminthe, Brugia malayi, Cytokines, Filariose lymphatique, Lymphocytes T, Macrophages, Monocytes.
- parasitologie : Filariose lymphatique, Lymphocytes T, Macrophages, Monocytes.
- Activation des macrophages, Animaux, Humains, Interactions hôte-parasite, Souris, Spécificité d'hôte.
English descriptors
- KwdEn :
- Animals, Antigens, Helminth (immunology), Brugia malayi (immunology), Cytokines (biosynthesis), Cytokines (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Host Specificity, Host-Parasite Interactions, Humans, Macrophage Activation, Macrophages (immunology), Macrophages (parasitology), Macrophages (pathology), Mice, Monocytes (immunology), Monocytes (parasitology), Monocytes (pathology), T-Lymphocytes (immunology), T-Lymphocytes (parasitology), T-Lymphocytes (pathology).
- MESH :
- chemical , biosynthesis : Cytokines.
- chemical , immunology : Antigens, Helminth, Cytokines.
- immunology : Brugia malayi, Elephantiasis, Filarial, Macrophages, Monocytes, T-Lymphocytes.
- parasitology : Elephantiasis, Filarial, Macrophages, Monocytes, T-Lymphocytes.
- pathology : Macrophages, Monocytes, T-Lymphocytes.
- Animals, Host Specificity, Host-Parasite Interactions, Humans, Macrophage Activation, Mice.
Abstract
Lymphatic filariasis is a mafor tropical disease affecting approximately 120 million people worldwide. Patent infection, by and large, is clinically asymptomatic but is associated with the inability of T cells to proliferate or produce IFN-γ in response to parasite antigen. Monocyte dysfunction is one hypothesis felt to explain the lack of an antigen-specific T cell response. In fact, monocytes from filaria-infected individuals have been shown to be studded with internalized filarial antigens. Understanding how the phenotype and the function of these monocytes are altered through the internalization of these parasite antigens is one of the areas our laboratory has focused on. In fact, the existence and/or function of alternatively activated macrophages in murine models of filarial infections have been extensively studied. Whether this population of macrophages can be induced in human filarial infections is the main focus of this review.
DOI: 10.1007/978-1-4614-6217-0_6
PubMed: 23456837
Affiliations:
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macrophages</term><term>Animaux</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Cytokines (biosynthèse)</term><term>Cytokines (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Humains</term><term>Interactions hôte-parasite</term><term>Lymphocytes T (anatomopathologie)</term><term>Lymphocytes T (immunologie)</term><term>Lymphocytes T (parasitologie)</term><term>Macrophages (anatomopathologie)</term><term>Macrophages (immunologie)</term><term>Macrophages (parasitologie)</term><term>Monocytes (anatomopathologie)</term><term>Monocytes (immunologie)</term><term>Monocytes (parasitologie)</term><term>Souris</term><term>Spécificité d'hôte</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes T</term><term>Macrophages</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Cytokines</term><term>Filariose lymphatique</term><term>Lymphocytes T</term><term>Macrophages</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Macrophages</term><term>Monocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphocytes T</term><term>Macrophages</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Macrophages</term><term>Monocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Macrophages</term><term>Monocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Host Specificity</term><term>Host-Parasite Interactions</term><term>Humans</term><term>Macrophage Activation</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des macrophages</term><term>Animaux</term><term>Humains</term><term>Interactions hôte-parasite</term><term>Souris</term><term>Spécificité d'hôte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis is a mafor tropical disease affecting approximately 120 million people worldwide. Patent infection, by and large, is clinically asymptomatic but is associated with the inability of T cells to proliferate or produce IFN-γ in response to parasite antigen. Monocyte dysfunction is one hypothesis felt to explain the lack of an antigen-specific T cell response. In fact, monocytes from filaria-infected individuals have been shown to be studded with internalized filarial antigens. Understanding how the phenotype and the function of these monocytes are altered through the internalization of these parasite antigens is one of the areas our laboratory has focused on. In fact, the existence and/or function of alternatively activated macrophages in murine models of filarial infections have been extensively studied. Whether this population of macrophages can be induced in human filarial infections is the main focus of this review.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Semnani, Roshanak Tolouei" sort="Semnani, Roshanak Tolouei" uniqKey="Semnani R" first="Roshanak Tolouei" last="Semnani">Roshanak Tolouei Semnani</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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